Syntheses of isotope??labeled tobacco??specific nitrosamines and their metabolites

D Desai, J Krzeminski, K El??Bayoumy…

文献索引：Desai, Dhimant; Krzeminski, Jacek; El-Bayoumy, Karam; Amin, Shantu Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 5 p. 226 - 230

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被引用次数: 2

摘要

Abstract We report here on the syntheses of three deuterium-labeled tobacco-specific nitrosamines namely [2, 4, 5, 6-d 4] nitrosonornicotine ([2, 4, 5, 6-d 4] NNN), 4- (methylnitrosamino)-1-(3-[2, 4, 5, 6-d 4] pyridyl)-1-butanone ([2, 4, 5, 6-d 4] NNK), and 4- (methylnitrosamino)-1-(3-[2, 4, 5, 6-d 4] pyridyl)-1-butanol ([2, 4, 5, 6-d 4] NNAL). A metabolite of NNK and myosmine, 4-hydroxy-1-(3-[2, 4, 5, 6-d 4] pyridyl)-1-butanone, was ...