Secondary amides of (R)-3, 3, 3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase

TD Aicher, RC Anderson, J Gao, SS Shetty…

文献索引：Journal of Medicinal Chemistry, , vol. 43, # 2 p. 236 - 249

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被引用次数: 54

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The desired compounds were prepared by a variety of methods, as outlined in Scheme 1. Conjugation of 4-substituted piperidines, 2-chloroaniline, cyclohexylamine, and ...