Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors

…, J Zhang, JL Flippen-Anderson, M Zhang…

文献索引：Kozikowski, Alan P.; Araldi, Gian Luca; Boja, John; Meil, William M.; Johnson, Kenneth M.; Flippen-Anderson, Judith L.; George, Clifford; Saiah, Eddine Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1962 - 1969

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被引用次数: 46

摘要

The synthesis and monoamine transporter activity of additional members of a series of 3, 4- disubstituted piperidines (truncated analogues of the WIN series) are described. All members of this series were prepared from arecoline hydrobromide in optically pure form and were evaluated for their ability to inhibit high affinity uptake of dopamine (DA), serotonin (5-HT) and norepinephrine (NE) into rat brain nerve endings (synaptosomes). Most of the ...