Tetrahedron: Asymmetry

Synthesis of N-Boc-(R)-α-phenyl-γ-aminobutyric acid using an in situ diastereoselective protonation strategy

M Calmès, F Escale, J Martinez

文献索引：Calmes, Monique; Escale, Francoise; Martinez, Jean Tetrahedron Asymmetry, 2002 , vol. 13, # 3 p. 293 - 296

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被引用次数: 11

摘要

The synthesis of (±)-N-phthalyl α-phenyl-γ-aminobutyric acid and its asymmetric transformation via ketene formation have been investigated, allowing, after hydrolysis and amine protection, the preparation of the enantiomerically pure N-Boc-(R)-α-phenyl-γ- aminobutyric acid.