C??Glycosyl Amino Acids through Hydroboration–Cross??Coupling of exo??Glycals and Their Application in Automated Solid??Phase Synthesis

S Koch, D Schollmeyer, H Löwe…

文献索引：Koch, Stefan; Schollmeyer, Dieter; Loewe, Holger; Kunz, Horst Chemistry - A European Journal, 2013 , vol. 19, # 22 p. 7020 - 7041

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被引用次数: 14

摘要

Abstract O-Glycosylation is one of the most important post-translational modifications of proteins. The attachment of carbohydrates to the peptide backbone influences the conformation as well as the solubility of the conjugates and can even be essential for binding to specific ligands in cell–cell interactions or for active transport over membranes. This makes glycopeptides an interesting class of compounds for medical applications. To ...