Mild and efficient oxidative aromatization of 4??substituted??1, 4??dihydropyrimidines using (diacetoxyiodo) benzene

NN Karade, SV Gampawar, NP Tale…

文献索引：Karade, Nandkishor N.; Gampawar V, Sumit; Tale, Nilesh P.; Kedar, Sanjay B. Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 3 p. 740 - 744

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被引用次数: 8

摘要

4-Aryl-3, 4-dihydropyrimidin-2 (1H)-ones (Biginelli compounds, DHPMs) represent an azaheterocyclic system of remarkable pharmacological profile [1]. It was investigated during 1980s and 1990s that DHPMs exhibit a similar pharmacological profile to the Hantzsch's 1, 4- dihydropyridine calcium channel modulators of the nifedipine type drugs [2]. In particular, the 2-heterosubstituted 4-aryl-1, 4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters were ...