The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

JM Matthews, N Qin, RW Colburn, SL Dax…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 8 p. 2922 - 2926

全文：HTML全文

被引用次数: 18

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Investigation of alternate scaffolds related to compound 2, using chemistry outlined in Scheme 1, resulted in the synthesis of compounds 4, 19 and 20 as shown in Table 1. Though several of the compounds had similar potency to ...