Synthesis and antihyperlipidemic activity of novel condensed 2-fluoromethylpyrimidines

…, VK Raskar, KS Jain, M Maheshwar, S Gadhwe…

文献索引：Kathiravan, Muthu K.; More, Kapil D.; Raskar, Vikas K.; Jain, Kishor S.; Maheshwar, Mukta; Gadhwe, Sandeep; Jain, Dilpesh P.; Nagras, Madhuri A.; Phoujdar, Manisha S. Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4286 - 4292

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被引用次数: 2

摘要

Abstract A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated for antihyperlipidemic activity in high fat diet fed hyperlipidemic Sprague–Dawley rats. The aim of this study was to investigate the effect of the fluorine atom at the 2-methyl position of these compounds. Most of the synthesized compounds significantly affected the lipid profile of the test animals. Compound IIIb exhibited remarkably best effects in ...