New approaches to the industrial synthesis of HIV protease inhibitors

Y Honda, S Katayama, M Kojima, T Suzuki…

文献索引：Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070

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被引用次数: 35

摘要

... Biomol. Chem., 2004, 2, 2061-2070 Show Compounds Show Chemical Terms. ... We then examined hydrophobic protection of the 2-hydroxyl group to facilitate isolation by extraction with organic solvents. ... i) (a) NaBH 4 , CH 2 Cl 2 , MeOH, −4 °C, (b) 1 M HCl, 77%, (ii) H 2 , 5% Pd ...