Designing better coumarin-based fluorogenic substrates for PTP1B
CP Holmes, N Macher, JR Grove, L Jang…
文献索引：Holmes, Christopher P.; Macher, Natalie; Grove, J. Russell; Jang, Larry; Irvine, Jennifer D. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3382 - 3385
As part of a program to develop better PTP1B fluorogenic substrates that more closely mimic the functionality found in the natural substrate, we have prepared and evaluated nine novel analogs of 4-methylumbelliferone phosphate (MUP) with a variety of additional groups occupying the second phosphate binding pocket.
