Biochemistry

Unusual mechanism for an aminomutase rearrangement: Retention of configuration at the migration termini

W Mutatu, KL Klettke, C Foster, KD Walker

文献索引：Klettke, Karin L.; Sanyal, Sanjit; Mutatu, Washington; Walker, Kevin D. Journal of the American Chemical Society, 2007 , vol. 129, # 22 p. 6988 - 6989

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被引用次数: 43

摘要

The phenylalanine aminomutase from Taxus catalyzes the vicinal exchange of the amino group and the pro-3 S hydrogen of (2 S)-α-phenylalanine to make (3 R)-β-phenylalanine. While the migration of the amino group from C2 of the substrate to C3 of the product is already known to proceed intramolecularly with retention of configuration, the stereochemistry of the hydrogen transfer remained unknown, until now. The chemical ...