Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure–activity relationship study based on inhibitors for the Wnt response
M Lanier, D Schade, E Willems, M Tsuda…
文献索引：Lanier, Marion; Schade, Dennis; Willems, Erik; Tsuda, Masanao; Spiering, Sean; Kalisiak, Jaroslaw; Mercola, Mark; Cashman, John R. Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 697 - 708
Human embryonic stem cell-based high-content screening of 550 known signal transduction modulators showed that one “lead”(1, a recently described inhibitor of the proteolytic degradation of Axin) stimulated cardiomyogenesis. Because Axin controls canonical Wnt signaling, we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt-dependent, and we developed a structure–activity relationship to optimize the ...
