Synthesis and structure–activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure

…, A Kakefuda, H Yamada, T Ogiyama, T Taguchi…

文献索引：Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Ogiyama, Takashi; Taguchi, Taku; Sakamoto, Shuichi Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 725 - 734

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被引用次数: 13

摘要

In the context of heart failure and myocardial ischemia reperfusion, the activity of the sodium– calcium exchanger can lead to calcium overload, which in turn can lead to contractile dysfunction and arrhythmia. Therefore, NCX is an attractive target for treatment of heart failure and myocardial ischemia reperfusion. We have designed and synthesized a series of benzyloxyphenyl derivatives as potential NCX inhibitors, based on compound 4. These ...