Characterization of 4-methyl-2-oxo-1, 2-dihydroquinolin-6-yl acetate as an effective antiplatelet agent

N Priya, A Gupta, K Chand, P Singh, A Kathuria…

文献索引：Priya, Nivedita; Gupta, Anjali; Chand, Karam; Singh, Prabhjot; Kathuria, Abha; Raj, Hanumantharao G.; Parmar, Virinder S.; Sharma, Sunil K. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 11 p. 4085 - 4094

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被引用次数: 26

摘要

We have studied earlier a membrane bound novel enzyme Acetoxy Drug: protein transacetylase identified as Calreticulin Transacetylase (CRTAase) that catalyzes the transfer of acetyl groups from polyphenolic acetates (PAs) to the receptor proteins and thus modulating their biological activities. In this communication, we have reported for the first time that acetoxy quinolones are endowed with antiplatelet action by virtue of causing ...