Synthesis and biological evaluation of 3, 4-diphenyl-1, 2, 5-oxadiazole-2-oxides and 3, 4-diphenyl-1, 2, 5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide …

C Velázquez, PNP Rao, R McDonald…

文献索引：Velazquez, Carlos; Rao, P.N. Praveen; McDonald, Robert; Knaus, Edward E. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 8 p. 2749 - 2757

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被引用次数: 53

摘要

A group of 3, 4-diphenyl-1, 2, 5-oxadiazole-2-oxides (3, 4-diphenylfuroxans) and the corresponding N-desoxy 3, 4-diphenyl-1, 2, 5-oxadiazoles (3, 4-diphenylfurazans) analogs, were synthesized for in vitro evaluation as hybrid cyclooxygenase (COX) inhibitor/nitric oxide donor agents. Reaction of 1-[4-(methylsulfonyl) phenyl]-2-phenylethene with an aqueous sodium nitrite solution in acetic acid afforded a mixture (3: 1 ratio) of the ...