Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide

S Vandevoorde, KO Jonsson, CJ Fowler…

文献索引：Vandevoorde, Severine; Jonsson, Kent-Olov; Fowler, Christopher J.; Lambert, Didier M. Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1440 - 1448

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被引用次数: 40

摘要

The endogenous fatty acid amide anandamide (AEA) has, as a result of its actions on cannabinoid and vanilloid receptors, a number of important pharmacological properties including effects on nociception, memory processes, spasticity, and cell proliferation. Inhibition of the metabolism of AEA, catalyzed by fatty acid amide hydrolase (FAAH), potentiates the actions of AEA in vivo and therefore may be a useful target for drug ...