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Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo

GW Rewcastle, GJ Atwell, BC Baguley…

文献索引:Rewcastle, Gordon W.; Atwell, Graham J.; Baguley, Bruce C.; Calveley, Stephen B.; Denny, William A. Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 793 - 799

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被引用次数: 116

摘要

In a search for compounds related to flavoneacetic acid with activity against solid tumors, a series of methyl-, methoxy-, chloro-, nitro-, and hydroxy-substituted xanthenone-4-acetic acids have been synthesized and evaluated against subcutaneously implanted colon ...