New antianginal nitro esters with reduced hypotensive activity. Synthesis and pharmacological evaluation of 3-[(nitrooxy) alkyl]-2H-1, 3-benzoxazin-4 (3H)-ones

F Benedini, G Bertolini, R Cereda, G Dona…

文献索引：Benedini, Francesca; Bertolini, Giorgio; Cereda, Roberta; Dona, Giancarlo; Gromo, Gianni; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 130 - 136

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被引用次数: 65

摘要

New nitro ester 3-[(nitrooxy) alkyll-W-1, 3-benzoxazin-4 (3~-ones show marked inhibitory activity against ischemia-induced electrocardiographic changes, with only limited systemic hemodynamic effects, and are reported in the present study. These new nitro vasodilators are potent inhibitors of the electrocardiographic T-wave and ST segment elevation induced by intravenous or intracoronary administration of Arg-vasopressin or methacholine in the ...