New GM1 ganglioside derivatives for selective single and double labelling of the natural glycosphingolipid skeleton

…, G Schwarzmann, A de Meijere, SW Hell

文献索引：Polyakova, Svetlana M.; Belov, Vladimir N.; Yan, Sergey F.; Eggeling, Christian; Ringemann, Christian; Schwarzmann, Guenter; De Meijere, Armin; Hell, Stefan W. European Journal of Organic Chemistry, 2009 , # 30 p. 5162 - 5177

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被引用次数: 18

摘要

Abstract Selective single and double labelling of the natural ganglioside GM1 enables one to introduce various markers into different parts of the glycosphingolipid molecule without changing the natural skeleton. To that end, N-Fmoc-2-amino-, N-Fmoc-18-amino-and S- (ethoxythiocarbonyl)-18-mercaptostearic acids have been prepared and coupled with the primary amino group in the sphingosine part of lyso-GM1 and deAc-deAcyl-GM1 ...