Abstract An efficient synthesis of [2, 3-bis (acyloxy) propyl] phosphonocholines is described. The reaction pathway for the synthesis involves the Michaelis-Arbuzov reaction of allyl bromide with triethyl phosphite and epoxidation of the resulting diethyl (prop-2-en-1-yl) phosphonate (1) with m-CPBA to afford the phosphonated diol (3). The acylation of diol (3) with carboxylic acids gave a series of diacyloxypropylphosphonates (4). The introduction ...
