Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi

…, S Misra, J Gupta, S Misra-Bhattacharya

文献索引：Sashidhara, Koneni V.; Singh, Suriya P.; Misra, Sweta; Gupta, Jyoti; Misra-Bhattacharya, Shailja European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 230 - 235

全文：HTML全文

被引用次数: 21

摘要

Bioassay guided fractionation of ethanolic extract of the leaves of Bauhinia racemosa led to the isolation of galactolipid and catechin class of the compounds (1–7) from the most active n-butanol fraction (F4). Among the active galactolipids, 1 emerged as the lead molecule which was active on both forms of lymphatic filarial parasite, Brugia malayi. It was found to be better than the standard drug ivermectin and diethylcarbamazine (DEC) in terms of ...