Molecules

Synthesis and antitumor activity of 5-trifluoromethyl-2, 4-dihydropyrazol-3-one nucleosides

IM Abdou, AM Saleh, HF Zohdi

文献索引：Abdou, Ibrahim M.; Saleh, Ayman M.; Zohdi, Hussein F. Molecules, 2004 , vol. 9, # 3 p. 109 - 116

全文：HTML全文

被引用次数: 64

摘要

Abstract: 2, 4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by 1 H and 13 C- NMR spectroscopy. Glucoside 3b shows an in vitro IC 50 value of 16.4 µM against proliferation of the human promyelotic leukemia (HL60) cell line.