Tandem facial amphiphiles for membrane protein stabilization

…, R Stroud, B Byrne, U Gether, SH Gellman

文献索引：Chae, Pil Seok; Gotfryd, Kamil; Pacyna, Jennifer; Miercke, Larry J. W.; Rasmussen, Soren G. F.; Robbins, Rebecca A.; Rana, Rohini R.; Loland, Claus J.; Kobilka, Brian; Stroud, Robert; Byrne, Bernadette; Gether, Ulrik; Gellman, Samuel H. Journal of the American Chemical Society, 2010 , vol. 132, # 47 p. 16750 - 16752

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被引用次数: 46

摘要

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.