Asymmetric sulfoxidation catalyzed by a vanadium-containing bromoperoxidase

M Andersson, A Willetts…

文献索引：Andersson, Malin; Willetts, Andrew; Allenmark, Stig Journal of Organic Chemistry, 1997 , vol. 62, # 24 p. 8455 - 8458

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被引用次数: 120

摘要

A vanadium-containing bromoperoxidase (VBrPO) from the alga Corallina officinalis has been shown to catalyze the stereoselective oxidation of some aromatic bicyclic sulfides to the corresponding (S)-sulfoxides in high (up to 91%) ee. Hydrogen peroxide was found to have a large effect on the catalyzed reaction, most likely due to an inhibition of VBrPO. High optical and chemical yields were found to be favored by a continuous slow addition of ...