Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin

G Bhattacharya, MM Salem, KA Werbovetz

文献索引：Bhattacharya, Gautam; Salem, Manar M; Werbovetz, Karl A Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2395 - 2398

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被引用次数: 47

摘要

Novel dinitroaniline sulfonamides based on the herbicide oryzalin 3 were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound 20 displays improved potency against leishmanial tubulin and is 13.4-fold more active ...