3D-QSAR studies of heterocyclic quinones with inhibitory activity on vascular smooth muscle cell proliferation using pharmacophore-based alignment

…, Y Lee, S Park, HJ You, RY Lee, SY Lee, S Choi

文献索引：Ryu, Chung-Kyu; Lee, Yoonji; Park, Seul-gi; You, Hea-Jung; Lee, Ra-Young; Lee, Seung-Yon; Choi, Sun Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9772 - 9779

全文：HTML全文

被引用次数: 16

摘要

The abnormal proliferation and migration of vascular smooth muscle cells (SMCs) play an important role in the pathology of coronary artery atherosclerosis and restenosis following angioplasty. It was reported that some heterocyclic quinone derivatives such as 6-arylamino- quinoxaline-5, 8-diones and 6-arylamino-1H-benzo [d] imidazole-4, 7-diones have inhibitory activity on rat aortic smooth muscle cell (RAoSMC) proliferation. To understand the ...