文献索引：Crowell, Thomas A.; Halliday, Basil D.; McDonald, John H.; Indelicato, Joseph M.; Pasini, Carol E.; Wu, Ernie C. Y. Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2436 - 2442
Figure 3.(1) Zn, HC1, DMF/THF;(2)(a) Ph2CN2 or (b) Bu, NHS04/NaHC03, CH, CHCH&ir;(3)(a) PCl,, py,(b) i-BuOH,(c) HzO;(4) t-Boc (or alloc)(2-aminothiazol-4-y1)-2 (Z)- 0ximinoa~ etyl-OCO~ C~ N~(M e 0)~, N-methylmorpholine, CH2C12. activate the free acid in the presence of N-methylmorpholine. 1 The resultant carbacephems (10a, b) were then ready for conversion to the desired sulfones lla-i. The conversion to the sulfones was ...
