Tetrahedron

Synthesis of the novel pyrrolo [2, 1-d][1, 2, 5] benzotriazepine, pyrrolo [2, 1-e][1, 3, 6] benzotriazocine and pyrrolo [1, 2-a] tetrazolo [1, 5-d][1, 4] benzodiazepine ring …

D Korakas, A Kimbaris, G Varvounis

文献索引：Korakas, Demetrios; Kimbaris, Athanasios; Varvounis, George Tetrahedron, 1996 , vol. 52, # 32 p. 10751 - 10760

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被引用次数: 22

摘要

Selective reduction of 2-azidomethyl-1-(2-nitrophenyl) pyrrole 5 afforded 2-aminomethyl-1- (2-nitrophenyl) pyrrole 10. Pyrrolo [1, 2-a] quinoxaline 15 is obtained by treating aminoester 12 with formaldehyde. Diamine 8 reacts with either formaldehyde or benzaldehyde to give pyrrolo [1, 2-a] quinoxaline 19. Compound 10 was reductively cyclised to pyrrolo [2, 1-d][1, 2, 5]-benzotriazepine 22. Intramolecular coupling of diamine 8 with triphosgene or carbon ...