Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase
JM Chambers, PA Hill, JA Aaron, Z Han…
文献索引：Chambers, Jennifer M.; Hill, P. Aru; Aaron, Julie A.; Christiansen, David W.; Han, Zhaohui; Kuzma, Nicholas N.; Dmochowski, Ivan J. Journal of the American Chemical Society, 2009 , vol. 131, # 2 p. 563 - 569
129Xe NMR biosensors are promising agents for early disease detection, especially when their interactions with target biomolecules can perturb 129Xe chemical shifts well beyond the typical field inhomogeneity of clinical MRI. We introduce human carbonic anhydrase (CA) as a single-binding-site enzyme for studying xenon biosensor− protein interactions. A xenon-binding cryptophane was substituted with linkers of varying lengths to p- ...
