Palladium-catalyzed double-carbonylation of alkenyl halides with secondary amines to give α-keto amides

…, H Yanagihara, F Ozawa, A Yamamoto

文献索引：Son, Tae-il; Yanagihara, Hisayoshi; Ozawa, Fumiyuki; Yamamoto, Akio Bulletin of the Chemical Society of Japan, 1988 , vol. 61, p. 1251 - 1258

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被引用次数: 32

摘要

The double-carbonylation reaction of alkenyl halides with diethylamine in the presence of palladium catalysts has been examined in detail. The reaction gives α-keto amide together with amide, the single-carbonylation by-product. The yield of α-keto amide is strongly dependent on the nature of alkenyl halide. Alkenyl bromides or iodides having phenyl group (s) as substituent (s) on the vinyl group are successfully double-carbonylated under ...