Optical Resolution by Preferential Crystallization of (R5)-. ALPHA.-Amino-. GAMMA.-butyrolactone Hydrochloride.

…, M YASUDA, T MORISHITA, H KUROKAWA

文献索引：Shiraiwa, Tadashi; Miyazaki, Hideya; Ohta, Atsushi; Waki, Yukitaka; Yasuda, Masahiro; Morishita, Toshimitsu; Kurokawa, Hidemoto Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 12 p. 2322 - 2325

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被引用次数: 5

摘要

(RS)-α-Amino-γ-butyrolactone hydrochloride [(RS)-ABL· HCl] was found to exist as a conglomerate based on the infrared spectrum, solubility, and melting point. Optical resolution by preferential crystallization of (RS)-ABL· HCl was achieved to yield (R)-and (S)- ABL· HCl. The obtained (R)-and (S)-ABL· HCl were recrystallized, taking into account the solubility of (RS)-ABL· HCl to give optically pure (R)-and (S)-ABL· HCl.