Unusual reaction of endic anhydride with 2-methyl-2-phenylaminopropanenitrile

VA Pal'chikov, IN Tarabara, NY Kol'tsov…

文献索引：Pal'chikov; Tarabara; Kol'tsov; Kas'yan Russian Journal of Organic Chemistry, 2006 , vol. 42, # 4 p. 610 - 611

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摘要

Many amido acids derived from commercially available bicyclo[2.2.1]hept 5 ene endo 2,endo 3 di carboxylic anhydride (I, endic anhydride) exhibit strong and versatile biological activity [1, 2]. We have studied the reaction of compound I with 2 methyl 2 phenylaminopropanenitrile (II) [3]. Under standard conditions for synthesis of amido acids (benzene, 20s 25 C) no amido acid III was formed over a period of 17 days, and up to 50% of initial amino nitrile II was ...