Fluorinated 2′-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities

…, N Oswal, P Dandawate, RA Rub, J Deshpande…

文献索引：Padhye, Subhash; Ahmad, Aamir; Oswal, Nikhil; Dandawate, Prasad; Rub, Rukhsana A.; Deshpande, Jyoti; Swamy, K. Venkateswara; Sarkar, Fazlul H. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5818 - 5821

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被引用次数: 30

摘要

Chalcones are involved in the synthesis of flavonoids and are themselves known to exhibit multiple pharmacological properties. However, compared to other structurally similar phytochemicals like garcinol and curcumin, the therapeutic use of chalcones is limited because of their lower bioavailability and rapid metabolic clearance from biological system. In the present work, we have attempted to overcome these limitations in case of 2′- ...