Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl) thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol …

…, M Svirčev, V Kojić, G Bogdanović, V Popsavin

文献索引：Popsavin, Mirjana; Spaic, Sasa; Svircev, Milos; Kojic, Vesna; Bogdanovic, Gordana; Popsavin, Velimir Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6700 - 6704

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被引用次数: 10

摘要

2-(β-d-xylofuranosyl) thiazole-4-carboxamide (2) and two new tiazofurin analogues with 5- hydroxymethyl-2-methyl-tetrahydro-furo [2, 3-d][1, 3] dioxol-6-ol moiety as a sugar mimic (27 and 28) have been synthesized and evaluated for their in vitro antitumour activity against a panel of human tumour cell lines (K562, HL 60, Jurkat, Raji and HeLa). In contrast to previous literature reports, a metabolic MTT assay revealed remarkable cytotoxicity of 2 ...