A practical method for the synthesis of lycorine-type alkaloids with cis-B/C ring structure has been developed. Based on the reactions of aminocyclization, palladium-mediated arylation and especially cyclopropyl ring-opening rearrangement, the synthesis of anhydrocaranine,(±)-γ-lycorane and putative (±)-amarbellisine was accomplished.
![4-[2-[(6-bromobenzo[1,3]dioxol-5-yl)methylamino]ethyl]phenol结构式](https://image.chemsrc.com/caspic/140/34315-37-2.png)
![N-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-2-(4-methoxycyclohexa-1,4-dien-1-yl)ethanamine结构式](https://image.chemsrc.com/caspic/188/645388-77-8.png)