前往化源商城

Organic letters

Palladium-catalyzed synthesis of aromatic carboxylic acids with silacarboxylic acids

SD Friis, TL Andersen, T Skrydstrup

文献索引:Friis, Stig D.; Andersen, Thomas L.; Skrydstrup, Troels Organic Letters, 2013 , vol. 15, # 6 p. 1378 - 1381

全文:HTML全文

被引用次数: 23

摘要

Aryl iodides and bromides were easily converted to their corresponding aromatic carboxylic acids via a Pd-catalyzed carbonylation reaction using silacarboxylic acids as an in situ source of carbon monoxide. The reaction conditions were compatible with a wide range of functional groups, and with the aryl iodides, the carbonylation was complete within minutes. The method was adapted to the double and selective isotope labeling of tamibarotene.

 相关合成线路

~10%

~61%

~73%

~96%

~83%

~62%

~95%

~98%

~79%

~10%

~97%

~97%

~98%

~87%

~59%

~93%

~98%

~96%

~94%

~86%