Preliminary structure–activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug- …

…, H Gunosewoyo, H Guo, NC Ammerman…

文献索引：Onajole, Oluseye K.; Pieroni, Marco; Tipparaju, Suresh K.; Lun, Shichun; Stec, Jozef; Chen, Gang; Gunosewoyo, Hendra; Guo, Haidan; Ammerman, Nicole C.; Bishai, William R.; Kozikowski, Alan P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 4093 - 4103

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被引用次数: 34

摘要

Tuberculosis (TB) remains one of the leading causes of mortality and morbidity worldwide, with approximately one-third of the world's population infected with latent TB. This is further aggravated by HIV coinfection and the emergence of multidrug-and extensively drug- resistant (MDR and XDR, respectively) TB; hence the quest for highly effective antitubercular drugs with novel modes of action is imperative. We report herein the discovery of an ...