Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido-and 2 or 3-propanamido-thiazole analogs

…, GS Hassan, FAM Al-Omary, HI El-Subbagh

文献索引：El-Messery, Shahenda M.; Hassan, Ghada S.; Al-Omary, Fatmah A.M.; El-Subbagh, Hussein I. European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 615 - 625

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被引用次数: 37

摘要

A novel series of 2-acetamido and 2 or 3-propanamido derivatives of 4-or 5-substituted- thiazoles was designed and synthesized. Structure elucidation of the new synthesized compounds was attained by the use of 1H &13C NMR, and Mass spectrometry. Compounds were subjected to NCI in vitro assessment for their antitumor activity, at a single dose of 10μM of test compounds. Compounds bearing straight chain substituent or 4-phenyl ...