Novel 4-(morpholin-4-yl)-N′-(arylidene) benzohydrazides: synthesis, antimycobacterial activity and QSAR investigations

…, S Dangre, C Khachane, S Gore, B Deshmane

文献索引：Raparti, Vyankatesh; Chitre, Trupti; Bothara, Kailas; Kumar, Vanaja; Dangre, Sudarshan; Khachane, Chetan; Gore, Suraj; Deshmane, Bhavana European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 3954 - 3960

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被引用次数: 62

摘要

A series of 4-(morpholin-4-yl)-N′-(arylidene) benzohydrazides were synthesized using appropriate synthetic route. Antimycobacterial activity of the synthesized compounds (5a–5j) was carried out and percentage reduction in relative light units (RLU) was calculated using luciferase reporter phages (LRP) assay. Percentage reduction in relative light units (RLU) for isoniazid was also calculated. The test compounds showed significant antitubercular ...