Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives

…, PG Mandhane, SD Diwakar, SK Dabhade…

文献索引：Joshi, Ratnadeep S.; Mandhane, Priyanka G.; Diwakar, Santosh D.; Dabhade, Sanjay K.; Gill, Charansingh H. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3721 - 3725

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被引用次数: 68

摘要

In search for a new analgesic and anti-inflammatory agent with improved potency, we designed and synthesized a series of 3, 2-(4, 5-dihydro-5-(4-morphilinophenyl)-1H-pyarazol- 3-yl) phenols 6 (a–g) and its N-phenylpyrazol-1-carbothioamide 7 (a–g) by Claisan–Schmidt condensation followed by the reaction of hydrazine hydrate. All the synthesized compounds were assayed for their in vivo analgesic and anti-inflammatory activities. All the ...