Overall synthesis of GSK356278: quick delivery of a PDE4 inhibitor using a fit-for-purpose approach

G Guercio, D Castoldi, N Giubellina…

文献索引：Organic Process Research and Development, , vol. 14, # 5 p. 1153 - 1161

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被引用次数: 4

摘要

... Organic Process Research & Development. ... In fact, this procedure allowed minimizing the degradation of the coupling agent due to the interaction with hydrazinecarboxylate. ... led to the isolation of intermediate 9, a new stage 5 was introduced in the process (see Scheme 4 ...