Organic letters

Synthesis of 1, 2, 4-Triazolines: Base-Catalyzed Hydrazination/Cyclization Cascade of α-Isocyano Esters and Amides

D Monge, KL Jensen, I Marín, KA Jørgensen

文献索引：Monge, David; Jensen, Kim L.; Marin, Irene; Jorgensen, Karl Anker Organic Letters, 2011 , vol. 13, # 2 p. 328 - 331

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被引用次数: 46

摘要

A convenient, efficient synthesis of 1, 2, 4-triazolines from α-isocyano esters/amides and azodicarboxylates is presented. The developed reaction cascade is based on a base- catalyzed hydrazination-type reaction followed by a subsequent cyclization providing the triazolines in good to excellent yields (75− 99%). Phosphine-catalyzed and preliminary asymmetric phase-transfer catalysis approaches have also been investigated.