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Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives

…, L Kraus-Berthier, S Thirot, S Léonce…

文献索引:Tepe, Jetze J.; Madalengoitia, Jose S.; Slunt, Kelli M.; Werbovetz, Karl W.; Spoors, P. Grant; Macdonald, Timothy L. Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2188 - 2196

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被引用次数: 30

摘要

... Journal of Medicinal ... J. Med ... carbonate to afford 2. This latter was subsequently protected at the 4'-hydroxy position as its benzyloxycarbonyl derivative, 3. 20 Compound 3 was then converted into its 4β-activated derivative 4 by simple treatment with p-nitrophenylchloroformate in ...