Chemistry of 4-fluoroglutamic acid. Part 2. Separation of the diastereomers on a large scale. Preparation of cis-and trans-4-fluoro-5-pyrrolidone-2-carboxylic acids (4- …
V Tolman, V Vlasakova, J Němeček
文献索引：Tolman, V.; Vlasakova, V.; Nemecek, J. Journal of Fluorine Chemistry, 1993 , vol. 60, # 2.3 p. 185 - 191
Abstract Separation of the 4-fluoroglutamic acid diastereomers has been achieved by crystallizationof the hydrochlorides of their dialkyl esters 1b and 2d. Subsequent hydrolysis affordedthe diastereomers 1a and 2a in 100% steric purity. Conversion of the acids into the
