… ] imidazole. 5. Structure-activity relationships for side-chain nitro-, sulfone-, amino-, and aminosulfonyl-substituted analogs for therapy against anticholinesterase …
GA Koolpe, SM Lovejoy, DA Goff, KY Lin…
文献索引：Koolpe, Gary A.; Lovejoy, Steven M.; Goff, Dane A.; Lin, Kuei-Ying; Leung, Doris S.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1368 - 1376
Several quaternary imidazolium oxime derivatives incorporating side chains bearing nitro, sulfone, amino, and aminosulfonyl substituents were prepared and evaluated as treatment therapeutics for anti-AChE intoxication. In vivo test results in the mouse revealed that many of these compounds are highly effective in providing life-saving protection against the extremely toxic cholinesterase inhibitors soman and tabun. Several structure-activity ...
