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α??Boryl Isocyanides Enable Facile Preparation of Bioactive Boropeptides

A Zajdlik, Z Wang, JL Hickey, A Aman…

文献索引:Zajdlik, Adam; Wang, Zezhou; Hickey, Jennifer L.; Aman, Ahmed; Schimmer, Aaron D.; Yudin, Andrei K. Angewandte Chemie - International Edition, 2013 , vol. 52, # 32 p. 8411 - 8415 Angew. Chem., 2013 , vol. 125, # 32 p. 8569 - 8573

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被引用次数: 28

摘要

Boronic acids and their derivatives have found utility as synthetic building blocks,[1] chemosensors,[2] and as biologically active targets of synthesis.[3] Both the biological activity and chemical reactivity of boronic acids stem from boron s Lewis acidity. While useful in a broad range of applications, boron s propensity to undergo reactions with Lewis bases becomes problematic for functional-group compatibility during synthesis. Reagents that ...