Exhaustive glycosylation, pegylation, and glutathionylation of a [G4]??ene48 dendrimer via photoinduced thiol??ene coupling

…, Y Hed, A Marra, M Malkoch, CJ Hawker…

文献索引：Conte, Mauro Lo; Robb, Maxwell J.; Hed, Yvonne; Marra, Alberto; Malkoch, Michael; Hawker, Craig J.; Dondoni, Alessandro Journal of Polymer Science, Part A: Polymer Chemistry, 2011 , vol. 49, # 20 p. 4468 - 4475

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被引用次数: 42

摘要

Abstract The use of free-radical thiol-ene coupling (TEC) for the introduction of carbohydrate, poly (ethylene glycol), and peptide fragments at the periphery of an alkene functional dendrimer has been reported in this article. Four different sugar thiols including glucose, mannose, lactose, and sialic acid, two PEGylated thiols, and the natural tripeptide glutathione were reacted with a fourth generation alkene functional dendrimer [G4]-ene 48 ...