Suzuki–Miyaura arylations of tetramic acid sulfonates: Evaluation of lactam protection, sulfonate esters, and sterics

SJP Yoon??Miller, KM Dorward…

文献索引：Yoon-Miller, Sarah J. P.; Dorward, Kathryn M.; White, Kimberly P.; Pelkey, Erin T. Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 3 p. 447 - 454

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被引用次数: 9

摘要

3, 4-Diaryl-3-pyrrolin-2-ones 1a and 4-aryl-3-pyrrolin-2-ones 1b are important synthetic targets given their range of biological activity and utility as precursors to other compounds. 3, 4-Diaryl-3-pyrrolin-2-ones have been investigated as inhibitors of cyclooxygenase-II (COX- II)[1], vascular endothelial growth factor receptor (VEGF-R)[2], and protein kinase C (PKC)[3]. 3, 4-Diaryl-3-pyrrolin-2-ones have been used as building blocks for the preparation of the ...