Bioorganic & medicinal chemistry

Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase

YH Woo, RPM Fernandes, PJ Proteau

文献索引：Woo, Youn-Hi; Fernandes, Roberta P.M.; Proteau, Philip J. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2375 - 2385

全文：HTML全文

被引用次数: 65

摘要

Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin.