Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments

A Casimiro-Garcia, E De Clercq…

文献索引：Casimiro-Garcia, Agustin; De Clercq, Erik; Pannecouque, Christophe; Witvrouw, Myriam; Loftus, Tracy L; Turpin, Jim A; Buckheit Jr., Robert W; Fanwick, Phillip E; Cushman, Mark Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 11 p. 2827 - 2841

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被引用次数: 9

摘要

A new series of cosalane analogues incorporating two fragments of the dichlorodisalicylmethane pharmacophore has been synthesized. In order to identify the position for the attachment of the pharmacophore fragments to the steroid ring that results in the most potent analogues, two types of compounds were designed. In the first type, the two pharmacophore fragments were attached at C-3 and C-17 of the steroid ring by using ...